Genomic instability
The vulnerability of

the genetic code of life

Genomic instability

DNA damage, or genomic instability, can result from many factors, such as sun damage to the skin. As we grow older, this DNA damage can accumulate, leading to accelerated aging.⁽¹⁻²⁾

Genomic damage can result from many external and internal factors, such as UV, oxidative stress, and incomplete cell division. This damage leads to genetic mutations that can be easily corrected by DNA repair machinery in healthy individuals. However, as we grow older, our cells lose the ability to efficiently repair genetic lesions, leading to genomic instability and accelerated aging.

Protecting DNA from genomic damage could, therefore, help to reduce this detrimental aging process.⁽¹⁻²⁾


1. López-Otín C, et al. Cell. 2023;186(2):243–278.

2. Zhang S, et al. Cell Transplatation. 2018;27(5):729–738.