1st scientific research work on skin stem cells

1st scientific research on the inflamm’aging hypothesis

Discovery of proteasomal function impairment after UV irradiation

Discovery of modulation of heat shock proteins with senescence

1st dior skin cell model investigating the skin inflamm’aging process

COLLABORATION MODENA UNIVERSITY

Discovery of epidermal skin stem cells lose their proliferation potential under the effects of time and external aggressors

Discovery of loss of mitochondrial protein damage elimination with cell senescence

Discovery of the role of NOTCH, a partner for stem cell synchronization.

Development of new skin model to study the lipid mediator’s inflammatory response to stress

Definition of the biological specificities of delicate skin

Analysis of circadian modulation of proteasome activity

Impact of inflammatory mediators on clock genes expression in normal human epidermal keratinocytes

Thesis defense

Cutaneous and psychosocial assessment of apparent age and intersex perception differences

COLLABORATION CIRA

Use of CiRA* technology to create KiPS**

Setting up of exclusive model to study the wound healing & inflammatory linked hyperpigmentation

*CiRA: Cell Research and Application at Kyoto University;

**kiPS: keratinocytes derived from induced pluripotent stem cells

Investigation of the mechanism of heavy metal–induced oxidative stress production

Discovery of a specific senescence mechanism of glyoxal stress

Discovery of stem cells loss of energy with aging regenerated by plant extract

Development of an exclusive chronic inflammation model to quantify the microdamages within the premature aging process

Skin beauty perception and holistic dimension evaluation by AI