The acquired signal

that controls our DNA

Epigenetic alteration - Hallmarks of aging

Epigenetics is the study of how our environment and behaviors can affect our genes. Epigenetic changes are reversible and do not modify our DNA sequence directly, but they can determine how our genes work by turning them on or off. Certain changes have been associated with accelerated aging.⁽¹⁾

Epigenetics refers to reversible changes in gene activity that can positively or negatively control how our genes work.

Certain changes, such as modifications to the DNA methylation/demethylation balance, have been associated with accelerated aging and can be used as a predictor of this.

A future challenge in skin care is to learn how to reprogram skin cells, to reverse their age-related epigenetic alterations.⁽¹⁾


1. López-Otín C, et al. Cell. 2023;186(2):243–278.