CHRONIC INFLAMMATION
The quiet accumulation of

undesirable markers

Chronic inflammation - Hallmarks of aging

Inflammation is the body’s immune response to an internal or external aggression. Over time, exposure to these aggressions can promote long-lasting (chronic) inflammation, which contributes to the premature and visible signs of aging.⁽¹⁻²⁾

With age, our cells are exposed to many internal and external aggressions. This can lead to the production of deleterious molecules and the buildup of proinflammatory substances (promoting inflammation).


During the aging process, the initial temporary inflammation can progressively become chronic, which contributes to the premature and visible signs of aging. This is also known as “inflamm’aging”, and limiting the inflamm’aging process can help slow down skin aging.⁽¹⁻²⁾

References:

1. López-Otín C, et al. Cell. 2023;186(2):243–278.

2. Zhang S, et al. Cell Transplatation. 2018;27(5):729–738.